Twenty then – Today about Thirty-Five

Ten Problems About Twenty- Five Horses

It is understood that each horse always runs the distance in the same time and the horses have distinct speeds. You have no stopwatch, but can make deductions from the finishing order in the races. When deciding which horses to race, information obtained from previous races may be used. These conditions apply for all problems we present here. As often happens, the problem leads to many interest...

Thirty-five years of research into ribozymes and nucleic acid catalysis: where do we stand today?

Since the discovery of the first catalytic RNA in 1981, the field of ribozyme research has developed from the discovery of catalytic RNA motifs in nature and the elucidation of their structures and catalytic mechanisms, into a field of engineering and design towards application in diagnostics, molecular biology and medicine. Owing to the development of powerful protocols for selection of nuclei...

Fabry Disease: Thirty-Five Mutations

Background: Fabry disease, an X-linked inborn error of glycosphingolipid catabolism, results from mutations in the a-galactosidase A (a-Gal A) gene located at Xq22.1. To determine the nature and frequency of the molecular lesions causing the classical and milder variant Fabry phenotypes and for precise carrier detection, the a-Gal A lesions in 42 unrelated Fabry hemizygotes were determined. Mat...

It was twenty years ago today

To mark the 20 th anniversary of the commencement of [email protected] (now arXiv.org), I've adapted this article from one 1 that first appeared in Physics World and was later reprinted (with permission) in Learned Publishing. This version is closer to my original draft, with some updates for this occasion, plus an astounding 2 5 added footnotes. 2 [email protected] received its first email...

Twenty-Five Years Ago